Cu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines
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Cu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines
The transition-metal-catalyzed denitrogenative transannulation of pyridotriazoles represents an efficient method for the synthesis of fused nitrogen-containing heterocycles. This method is based on the ability of pyridotriazole to exist in an equilibrium with diazo-form A, which can be trapped with Rh(II) to form the reactive pyridyl carbene intermediate B, capable of reacting with terminal alk...
متن کاملCu-catalyzed transannulation reaction of pyridotriazoles with terminal alkynes under aerobic conditions: efficient synthesis of indolizines† †Electronic supplementary information (ESI) available: Experimental procedures and characterization for new compounds are provided. See DOI: 10.1039/c4sc03358b
The Cu(I)-catalyzed denitrogenative transannulation reaction of pyridotriazoles with terminal alkynes en route to indolizines was developed. Compared to the previously reported Rh-catalyzed transannulation reaction, this Cu-catalyzed method features aerobic conditions and much broader scope of pyridotriazoles and alkynes.
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ژورنال
عنوان ژورنال: Chemical Science
سال: 2015
ISSN: 2041-6520,2041-6539
DOI: 10.1039/c4sc03358b